Perhaps most disappointing of all, a new class of drugs (the so-called CETP-inhibitors), which several pharmaceutical companies have been enthusiastically developing for several years to raise HDL levels, has become a great disappointment. While these drugs do indeed increase HDL levels, they have not demonstrated an ability to improve cardiac risk — and on the contrary, studies appear to show a worsening in cardiac risk with some of these drugs. It is unclear today whether any CETP-inhibitors will ever reach the market.
Exercise! Exercise doesn’t necessarily mean losing weight, some people work out to gain weight or even maintain their current weight. I know that men, especially those with smaller figures try to body build to get a larger physique. Get a gym membership, and tell your trainer that you’re aiming to lower your cholesterol level but don’t want to lose any weight. try muscle building programs. Also, be sure to let your trainer know about your cardiac problem ! when doing cardio you need to watch out and take it gradually.
Ivan V. Pacold, MD, a cardiology professor at Loyola University’s Stritch School of Medicine in Chicago, says that lifestyle choices matter, and “even if these changes don’t show up directly in your cholesterol numbers, they can be lowering your risk for heart disease.” So if you haven’t made the change to a heart-healthy lifestyle, here are nine ways to get started.
Hayek T, Chajek-Shaul T, Walsh A, Agellon LB, Moulin P, Tall AR, Breslow JL. An interaction between the human cholesteryl ester transfer protein (CETP) and apolipoprotein A-I genes in transgenic mice results in a profound CETP-mediated depression of high density lipoprotein cholesterol levels. J Clin Invest. 1992 Aug;90(2):505–510. [PMC free article] [PubMed]
Foods like oatmeal, apples, prunes, and beans are high in soluble fiber, which keeps your body from absorbing cholesterol. Research shows that people who ate 5 to 10 more grams of it each day saw a drop in their LDL. Eating more fiber also makes you feel full, so you won’t crave snacks as much. But beware: Too much fiber at one time can cause abdominal cramps or bloating. Increase your intake slowly.
HDL plays an important role in transporting cholesterol from the peripheral tissues to the liver, where it can be excreted; this process is known as reverse cholesterol transport (RCT). (The liver is the main organ for excretion of cholesterol, doing so either directly or by converting cholesterol into bile acids.) It is important to remember that most HDL measured in the blood is derived from the liver and intestine. Therefore, the concentration of HDL in plasma does not reflect cholesterol efflux from blood vessels or the efficiency of RCT. Moreover, HDL function in RCT is not mirrored by HDL measurements. [2]
I very simply lowered my cholesterol 57 points in 6 month (257 to 200) and my ldl from 158 to 132 by not eating meat. It has now been a year since I stopped eating meat, I cannot exercise due to major surgery but lost 50lbs and will have my cholesterol retested in September for my annual checkup. I’m also planning on going back to the gym soon. High cholesterol runs in my family and I was determined not to go on medication like my mom. I gained 30lbs when I was injured, I did not intend to go back to my weight as a teenager when I stopped eating meat, just lower my cholesterol, that was just a perk. I never deprive myself of food, I eat fish and I don’t miss meat from my diet at all. It was a conscience choice I made to try and lower my cholesterol, no one told me to or advised me but it worked and I’m happy I took the path. Good luck to all and stay healthy!

HDL cholesterol is “good” because elevated blood levels have been associated with a lower risk of cardiovascular disease. However, clinical trials with experimental medications aimed at increasing HDL cholesterol levels, so far, have been largely disappointing. HDL researchers have gone back to the drawing board to figure out what it is about HDL that may reduce the risk of heart disease.

Foods like oatmeal, apples, prunes, and beans are high in soluble fiber, which keeps your body from absorbing cholesterol. Research shows that people who ate 5 to 10 more grams of it each day saw a drop in their LDL. Eating more fiber also makes you feel full, so you won’t crave snacks as much. But beware: Too much fiber at one time can cause abdominal cramps or bloating. Increase your intake slowly.
An under-valued element of bone and cardiovascular health is the role of Vitamin K2, which many individuals are unknowingly deficient in. Found in the Japanese breakfast delicacy “natto” (fermented soybeans), vitamin K2 not only helps remove calcium from the arteries and soft tissues to prevent atherosclerosis, but it also draws calcium into the bones to prevent the risk of fracture. Nattokinase, an enzyme found in natto, may help to increase HDL levels while lowering total cholesterol and LDL cholesterol levels, according to an Asia Pacific Journal of Clinical Nutrition study.
If you smoke, it’s time to pack it in. According to the American Heart Association, smoking reduces your HDL cholesterol levels, while increasing your risk of heart disease, high blood pressure and diabetes. If you’re a smoker, you need to quit. Once you stop smoking, you can significantly improve your HDL cholesterol level very quickly and start protecting your heart. And if you’re a non-smoker, you need to avoid exposure to second-hand smoke to prevent your health from going up in smoke.
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